Materiales
Materiales
Galangin Mitigates PM2.5-Induced Endoplasmic Reticulum Stress and Senescence in HaCaT Keratinocytes
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Exposure to particulate matter 2.5 (PM2.5) can negatively impact human skin, leading to issues such as wrinkle formation, skin aging, atopic dermatitis, and pigment spots. Galangin, a flavonoid...
Neuroprotective Potential of Human Platelet Lysate in Parkinson's Disease: Insights Into Oxidative Stress, Mitochondrial Dysfunction, Cell Death, and Reactive Gliosis in Experimental Models
04/07/2025 -
Graphical Abstract and Lay SummaryHuman platelet lysate (HPL) biotherapy promotes neuroprotection and reduces neurodegeneration in both cellular and animal models of rotenone (ROT)‐induced...
Computationally Guided Structural Modification of Centaureidin: A Novel Approach for Enhancing Antioxidant and Antitumor Activities for Drug Development
03/07/2025 -
Computationally guided modifications of centaureidin led to the development of CA4, demonstrating enhanced antioxidant and antitumor activities. Molecular docking and in vitro assays confirm...
Engineered‐Macrophage‐Escorted Rotaxane Nanoscavengers for Precise Diquat Detoxification
01/07/2025 -
This study develops macrophage‐escorted, ROS‐responsive rotaxane nanoscavengers loaded with charge‐neutralizing carboxymethyl α‐cyclodextrin and anti‐inflammatory 4‐octyl itaconate,...
Fast Determination of Protein Binding Constants and Sites to Active Flavonoids and Phenolic Acids by Affinity Capillary Electrophoresis and Fluorescence Spectroscopy
01/07/2025 -
Determination of binding ability of flavonoids/phenolic acids to HSA by affinity capillary electrophoresis and fluorescence spectroscopy.ABSTRACTThe interaction of small molecule drugs with human...
A Readily Degradable Polyvinyl Alcohol/Starch Membrane Containing Catechol-Grafted Microcrystalline Cellulose for Preserving Fruit Freshness
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Copolymer membranes based on polyvinyl alcohol (PVA) and starch suffer from low mechanical strength and poor fresh-produce preservation and degradation performance. Adding functional cellulose or...
Apelin‐13 Protects Against Airway Inflammation, Oxidative Stress, and Epithelial–Mesenchymal Transition in a Chronic Asthma Model
25/06/2025 -
Our findings demonstrate that Apelin‐13 treatment effectively alleviates key pathological features of asthma in OVA‐induced mice, including oxidative stress (reduced MDA and enhanced antioxidant...
Spatial profiling of carbonyl metabolites in diabetic cardiomyopathy by derivatization-assisted ambient mass spectrometry imaging
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Diabetic cardiomyopathy (DCM), a cardiac complication of diabetes, is characterized by diastolic dysfunction, myocardial fibrosis, and structural remodeling. Carbonyl-containing metabolites (CCMs)...
Anti‐Osteoporosis Activity of Lycopene Through ESR1: Network Pharmacology, Molecular Docking, Imaging Technology, and Experimental Validation
12/06/2025 -
Schematic of the mechanism of LYC in treating osteoporosis through the ESR1/PI3K/AKT pathway. LYC upregulates ESR1 expression and thus leads to the activation of the PI3K/AKT pathway, thereby...
Extraction, Structural Analysis, and Bioactivity of a Novel Polysaccharide From Corydalis yanhusuo Residues
10/06/2025 -
In this study, the polysaccharides extracted from the residue of Corydalis yanhusuo were purified, its structure was characterized, and its antioxidant and anti‐tumor activities in vitro were...
The antioxidant properties of green carbon dots: a review
08/03/2024 -
Since 2017, cities across the US have introduced shared e-scooter sharing programs that often co-exist with docked bikeshare services. Previous research has compared e-scooter and bikeshare...
Cu2O/CuVO3 Nano‐Heterojunction as a Highly Active Therapeutic Catalyst for Aggravating Redox Dyshomeostasis of Neoplastic Cells
01/06/2025 -
A belt‐like heterojunction nanozyme (CVO) with high peroxidase‐like activity is facilely developed for inducing apoptosis, ferroptosis, and cuproptosis via redox imbalance in tumors. DFT analysis...
A Smart DNA Nanoframework Enables Synergistic Photodynamic Therapy of Pancreatic Cancer
29/05/2025 -
A smart DNA nanoframework is constructed by precipitation polymerization and hybridization chain reaction, which enables the controlled co‐delivery of Cas9 ribonucleoprotein, hemin, and Ce6 for...
Design and Synthesized 3,4‐Dimethoxybenzene‐Based Fibrate Derivatives as Potential Hypolipidemic and Liver Protection Agents
23/05/2025 -
The natural compounds berberine, cryptopine, phillygenin, and dimethylmatairesinol exhibit notable antioxidant and anti‐inflammatory properties, closely associated with the 3,4‐dimethoxybenzene...
A Single‐Cell Atlas‐Inspired Hitchhiking Therapeutic Strategy for Acute Pancreatitis by Restricting ROS in Neutrophils
21/05/2025 -
This study discloses the first comprehensive single‐cell differentiation atlas of neutrophils during acute pancreatitis. A neutrophil‐targeted nanoreactor is developed to regulate neutrophil...
Size- and polymer-dependent toxicity of amorphous environmentally relevant micro- and nanoplastics in human bronchial epithelial cells
16/05/2025 -
Background
Knowledge of the toxicological impact of micro- and nanoplastics (MNPs) on the human airway epithelium is limited and almost exclusively based on experiments applying high...
Exploring Antibacterial, Antioxidant, Cytotoxic Potential of Oscillatoria sp.-Derived Metabolites and Their Molecular Docking with Estrogen Receptor-α
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Anthropogenic activities have led to the accumulation of carcinogenic toxicants in the food chain, posing severe risks to both human and animal health. Bioactive molecules derived from terrestrial...
Enhanced cell‐specific productivity through delayed supplementation of antioxidants in intensified processes
06/05/2025 -
Antioxidant supplementation to serum‐free culture media is a common strategy to enhance productivity through oxidative stress alleviation. In this study, it was hypothesized that certain...
Trigonelline Shields Chondrocytes from Oxidative Damage in Osteoarthritis through Activation of the Keap1/Nrf2/ARE Signaling Pathway
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Oxidative stress-induced chondrocyte damage is a key contributor to the progression of osteoarthritis (OA). While trigonelline (TG) possesses anti-inflammatory and antioxidant activities, its...
Unlocking the Potential of Medicago truncatula A17 Cell Suspension Cultures for Bioproduction of Astaxanthin and Canthaxanthin
02/05/2025 -
This study investigates the potential of metabolically engineered Medicago cell suspension cultures as a scalable and sustainable platform for the biosynthesis of high‐value ketocarotenoids,...
Influence of Polystyrene Microplastics on Mitochondrial Oxidative Damage in Renal and Muscular Tissues of the Freshwater Fish
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Polystyrene microplastics (PS-MPs), an emerging environmental contaminant, have attracted significant concern in recent years. This study aimed to evaluate mitochondrial oxidative damage in renal...
