Materiales
Materiales
Lactate‐Depleting Nanotherapy Reprograms the Immunometabolic Microenvironment to Overcome Biofilm Tolerance in Implant‐Associated Infections
02/10/2026 -
Lactate accumulation is associated with immunosuppression in implant‐associated infections (IAIs). A lactate‐depleting nanotherapy integrates immunometabolic remodeling with hypoxia‐activated...
Engineering Escherichia coli Nissle 1917 for the highly efficient biosynthesis of food-grade ergothioneine
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Ergothioneine (EGT) is a natural sulfur-containing amino acid possessing potent antioxidant activity. It demonstrates a range of beneficial biological functions, including anti-inflammatory,...
Antiproliferative Effects of Reynoutrin via Modulation of Oxidative Stress, Inflammation, and Apoptosis in Breast Cancer (MCF-7) and Prostate Cancer (PC-3) Cell Lines
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Reynoutrin, a bioactive flavonoid, exhibits various biological effects. Despite its toxic side effects, cisplatin is widely used to treat malignancies. This study aimed to assess the in vitro...
Sodium Sulfite as an Oxygen-Depletion-Based Chemical Model of Tumor Hypoxia In Vitro
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Hypoxia is a major determinant of tumor progression, yet most chemical hypoxia models rely on HIF stabilization rather than true oxygen depletion. Here, we evaluated sodium sulfite (SS), a direct...
Biocompatibility and Multifunctional Biological Evaluation of Flower-Shaped AgâCOâ and Ag/AgâCOâ Nanostructures in Diabetic Albino Mice
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The present study aimed to synthesize AgâCOâ and Ag/AgâCOâ nanostructures and to systematically investigate their physicochemical characteristics, biocompatibility, metabolic...
Therapeutic Potential of Pirfenidone in Adenine-Induced Chronic Kidney Disease: An Integrated Experimental and In Silico Study
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Chronic kidney disease (CKD) is a progressive condition characterized by sustained loss of renal function, frequently accompanied by fibrosis and oxidative stressâmediated damage. In this...
Antioxidant Dipeptides Enhance Stress Tolerance and Fermentation Performance of Lager Yeast During High-Gravity Brewing
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This study aimed to evaluate the effects of antioxidant dipeptides (AH, TY, and FC) on yeast stress tolerance, beer physicochemical properties, and sensory quality during high-gravity brewing. The...
Withaferin A-Loaded CS/β-GP Thermosensitive Hydrogel Attenuates Diabetes-Associated Renal Injury in a Diabetic Rat Model
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Abstract Diabetic nephropathy (DN) is a major complication of diabetes characterized by progressive renal dysfunction driven by oxidative stress and chronic inflammation. Although...
Acetylcholinesterase Inhibitory Co(II), Fe(II), Pd(II) and Ru(II) Complexes of a Tinoridine-based Schiff Base: Synthesis, Characterization and Antioxidant Evaluation
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In recent bioinorganic research, Schiff bases and transition metal complexes have attracted considerable attention owing to their low toxicity and enhanced biological activities. In this study,...
Protective Effect of a Polyherbal Formulation (Cardojith) Against Angiotensin II-induced Hypertension and Cardiomyocyte Hypertrophy Via Modulation of Oxidative Stress and MAPK Signalling
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Hypertension remains a critical contributor to cardiovascular morbidity, driven largely by angiotensin II (Ang II)-mediated oxidative stress, inflammation, and hypertrophic remodelling. Although...
Design, Synthesis, and Biological Evaluation of Anthracene Derivatives as Potent Antioxidants: Experimental, DFT, and Docking Studies
06/09/2026 -
A series of anthracene‐based derivatives exhibited exceptional antioxidant activity, with IC50 values surpassing ascorbic acid. DFT and molecular docking studies revealed efficient charge transfer...
Investigation of Antibacterial, Antioxidant, and Burn Wound Healing Effects of Green-Synthesized Silver Nanoparticles Using Alcoholic Extract of Peucedanum officinale
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Burn wounds remain a significant clinical challenge due to delayed tissue regeneration and the high risk of microbial infections. Green-synthesized silver nanoparticles using medicinal plant...
Comparative Therapeutic Effects of Lipid-Enriched and Ethanolic Garlic Extracts on DMBA-Induced Hepatic Carcinogenesis in Mice
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Garlic (Allium sativum) contains bioactive components with antioxidants and anti-inflammatory constituents with potential anticancer activity. We aimed to compare a petroleum-ether garlic...
Food‐Contact‐Compatible Superhydrophobic Coating Based on Starch for Low Adhesion and Fresh Preservation
26/08/2026 -
A food‐contact‐compatible superhydrophobic coating is fabricated using starch, palm wax, and quercetin. Demonstrating a water contact angle of 154.9°, this hierarchical composite minimizes...
An Acid‐Neutralizing Nanoreactor Counteracts Senescence‐Driven Cartilage Degeneration in Osteoarthritis
22/08/2026 -
An acid‐neutralizing nanoreactor, OLDH‐DP@POM, coordinately remodels the acidic, oxidative, inflammatory, and mechanical microenvironment of osteoarthritis. By attenuating chondrocyte senescence...
Electrokinetic assessment of Azelnidipine using Annona squamosa plant extract-derived Co3O4-ZnO nanocomposite fabricated pencil graphite electrode
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Herein, an advanced and highly selective voltammetric sensor based on a low-cost, disposable pencil graphite electrode decorated with a cobalt oxide–zinc oxide nanocomposite (Co3O4-ZnO@PGE) is...
Integrative Systems Pharmacology and Zebrafish Toxicity Profiling Reveal Piperine as a Multi-Target Modulator in DSS-Induced Intestinal Inflammation
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A bioactive alkaloid derived from Piper nigrum is piperine (PIP); it exhibits significant anti-inflammatory properties, but the mechanistic basis remains incomplete. This study integrates...
