Envase
Envase
Recent Advances in Engineering Ammonia Lyase for Biosynthesis of Aromatic Noncanonical Amino Acids
14/10/2026 -
Graphical Abstract and Lay SummaryEngineered ammonia lyases offer a powerful route for producing aromatic noncanonical amino acids (ncAAs). This review covers enzyme structure and catalytic...
Biomaterial‐Based Controlled Release Systems for Spinal Cord Remyelination
10/10/2026 -
Following spinal cord injury, inflammatory cytokines, glial scar formation, and demyelinated axons create a hostile microenvironment that inhibits oligodendrocyte progenitor cell maturation....
Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment
06/10/2026 -
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving...
Spatially resolved single cell atlas deciphers SAA1 inflammatory epithelial cells
29/09/2026 -
Alpha-1 antitrypsin (AAT) is a serine protease inhibitor that protects tissue from neutrophil elastase and other proteases, particularly in the lung. Mutations in SERPINA1, including the Z...
Design and Synthesis of Novel 1,2,3‐Triazole Conjugates Featuring Hydroxamic Acid and Sulfonamide Moieties: Exploring Dual Pharmacophores for Enhanced Biological Activity
17/09/2026 -
Design and synthesis of novel 1,2,3‐triazole conjugates featuring hydroxamic acid and sulfonamide moieties: exploring dual pharmacophores for enhanced biological activity.ABSTRACTA new series of...
Design, Synthesis, Antimycobacterial Evaluation, and In Silico Investigation of Benzisothiazole‐Based Hydrazide Derivatives as Potential Anti‐Tuberculosis Agents
19/09/2026 -
A novel series of benzisothiazole‐based hydrazide derivatives was designed, synthesized, and evaluated for antitubercular activity. Compound 8k emerged as the most potent candidate...
Anti-Inflammatory Role of Exopolysaccharides in Osteoarthritis via Modulation of Redox and Inflammatory/Catabolic Signaling Networks
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Osteoarthritis (OA) is a leading cause of disability worldwide, characterized by progressive cartilage degradation, chronic inflammation, and joint structural deterioration. Beyond its physical...
Multi-gene Regulation Based on Metabolites Analysis Reduces Nucleus Degradation and By-product Accumulation During Phytosterols Conversion to 9-Hydroxyandrost-4-ene-3,17-Dione
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Mycobacterium neoaurum HK86W is capable of converting phytosterols into the steroidal pharmaceutical intermediate 9-hydroxyandrost-4-ene-3,17-dione (9-OH-AD). In this study, systematic...
Functional Annotation Identifies 3-Oxoacyl Synthase III as a Druggable Target in Nocardia asteroides FDAARGOS1485: A Multi-Tier Structure-Guided Computational Discovery of Marine-Derived Therapeutic Leads
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Nocardiosis is a global life-threatening disease that predominantly affects immunodeficient populations. This disease is caused by the nosocomial pathogen Nocardia asteroides. Existing...
Towards engineering molecularly imprinted polymer-based sensors: linking design strategies to analytical and operational performance
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The use of molecularly imprinted polymers (MIPs) as synthetic receptors in sensing has expanded rapidly across diagnostic, environmental, food, and pharmaceutical applications, owing to their...
Withaferin A-Loaded CS/β-GP Thermosensitive Hydrogel Attenuates Diabetes-Associated Renal Injury in a Diabetic Rat Model
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Abstract Diabetic nephropathy (DN) is a major complication of diabetes characterized by progressive renal dysfunction driven by oxidative stress and chronic inflammation. Although...
AR/PARP Dual‐Targeting Bioactive Photosensitizer for Photo‐Immunotherapy of Prostate Cancer
09/09/2026 -
Prostate cancer poses a severe threat to men's health worldwide, and conventional therapeutic modalities are associated with various limitations. Photodynamic therapy (PDT) offers distinctive...
Acetylcholinesterase Inhibitory Co(II), Fe(II), Pd(II) and Ru(II) Complexes of a Tinoridine-based Schiff Base: Synthesis, Characterization and Antioxidant Evaluation
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In recent bioinorganic research, Schiff bases and transition metal complexes have attracted considerable attention owing to their low toxicity and enhanced biological activities. In this study,...
Characterization and Immunomodulatory Activity of a Sulfated Polysaccharide from Natto-Derived Bacillus subtilis
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Sulfated polysaccharides with significant biological activities were widely applied in functional food, cosmetic, biomedical and pharmaceutical industries. In this study, we established a...
Effective Abatement of Multidrug-resistant Pathogens Employing Natural Polyphenols and Polyphenol-based Formulations: A Systematic Review and Integrated Network Pharmacology Approach
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The upsurge in multidrug-resistant (MDR) bacterial pathogens poses a dire global public health concern, limiting the effectiveness of conventional antibiotics. Natural polyphenols and their...
Gegen Flavonoids and Huangqi Saponins Combination Ameliorates Diabetic Nephropathy By Modulating the GutâKidney Axis and Regulating Macrophage Polarization
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Diabetes nephropathy (DN) is a severe diabetic complication that is currently one of the most important causes of death in diabetic patients. Previous trials have shown that the combination of...
Synergistic Thermal Energy and Charge Carriers in an Fe‐MOF for Solar‐Driven Scalable and Selective Aniline Production
05/09/2026 -
We report NM‐101, a scalable Fe‐MOF that efficiently converts nitro compounds to anilines using sunlight. With high photothermal efficiency (58%) and a record TOF of 226.2 h−1, it enables...
