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Loureirin B inhibits Cervical Cancer Development by Blocking PI3K/AKT Signaling Pathway: Network Pharmacology Analysis and Experimental Validation
- Abstract Loureirin B (LB) is an iconic component of Chinese dragonâ??s blood that presents anti-cancer effects in gastric cancer and liver cancer. Although LB has shown benefits...
Advanced three?dimensional in vitro liver models to study the activity of anticancer drugs
19/06/2024 - Graphical Abstract and Lay Summary  3D liver aggregates formed with three main liver cell types such a hepatocytes, hepatic stellate cells and hepatic sinusoidal endothelial cells psented in vivo...
The medicinal chemistry of piperazines: A review
18/06/2024 - Medicinal chemistry of piperazine and its derivatives.The versatile basic structure of piperazine allows for the development and production of newer bioactive molecules that can be used to treat a...
Advantages and drawbacks of life cycle assessment application to the pharmaceuticals: a short critical literature review
19/06/2024 - Pharmaceuticals are among the most challenging products to assess by life cycle assessment (LCA). The main drawback highlighted by LCA practitioners is the lack of inventory data, both regarding...
Innovative Formulation Platform: Paving the Way for Superior Protein Therapeutics with Enhanced Efficacy and Broadened Applications
16/06/2024 - Protein therapeutics hold great promise for treating various diseases, yet their delivery remains challenging. This review introduces “Pcapsulation,” a protein formulation technology....
LCMS Based Untargeted Metabolic Profiling Revealed a Strong Association of Nanoselenium Treated Sesame (Sesamum indicum) Seed Bioactive Compounds as Novel Potential Disease Targets- A Nano-bioinformatics Approach
- Abstract The convergence of nanotechnology with bioinformatics and the study of plant secondary metabolites hold remarkable potential for transformative scientific breakthroughs....
Ruthenium(II) Polypyridyl Complexes with Benzoxazole Derivatives and Non?Innocent Ligands as Effective Antioxidants in Human Neuroblasts
14/06/2024 - The combination of benzoxazole derivatives with non?innocent ligands in the same ruthenium(II) polypyridyl complex is a suitable strategy to design new pharmacological tools with ROS?scavenging...
Total Synthesis of (15R)? and (15S)?Prostaglandin A2
14/06/2024 - From both pharmaceutical and structural perspectives, the large family of prostaglandins represent a truly remarkable class of natural products. Prostaglandin A2 is a tissue hormone naturally found...
Combining the Pharmaceutical and Toxicological Properties of Selected Essential Oils with their Chemical Components by GC?MS Analysis
11/06/2024 - In the current investigation, a comprehensive analysis was carried out on essential oils (EOs) extracted from six aromatic plant species, namely Rosmarinus officinalis, Pelargonium graveolens, Thymus...
Caffeine and Purine Derivatives: A Comprehensive Review on the Chemistry, Biosynthetic Pathways, Synthesis?Related Reactions, Biomedical Prospectives and Clinical Applications
12/06/2024 - Caffeine and purine derivatives represent interesting chemical moieties, which show various biological activities. Caffeine is an alkaloid that belongs to the family of methylxanthine alkaloids and...
A Structure?Based Design Strategy with Pyrazole?Pyridine Derivatives Targeting TNF? as Anti?inflammatory Agents: E?pharmacophore, Dynamic Simulation, Synthesis and In Vitro Evaluation
11/06/2024 - Any pathogenic attack, infection, or disease can initiate inflammation. It results in significant adverse consequences like inflammatory bowel disease, rheumatoid arthritis, etc. TNF? is one of the...
Bergenia ciliata—Phytochemistry and Pharmacology: A Review
01/09/2024 - Abstract Bergenia ciliata is considered a highly valued medicinal herb popularly known as ‘Pashaanbheda’ (means to dissolve stone) in the Indian System of Medicine...
Multifaceted Applications of Solid Lipid: A Comprehensive Review
01/09/2024 - Abstract Lipids originate from plant and animal sources and have significant roles in various fields, like pharmaceuticals, cosmetics, food, paint, leather, agriculture,...
Synthesis of R–GABA Derivatives via Pd(II) Catalyzed Enantioselective C(sp3)?H Arylation and Virtual Validation with GABAB1 Receptor for Potential leads
07/06/2024 - The enantioselective synthesis of GABAB1 inhibitor drug scaffolds are accomplished from easily accessible GABA via Pd?catalyzed C(sp3)?H activation using the chiral ligand acetyl–protected amino...
Starch?chitosan blends: A comprehensive review on the preparation, physicochemical properties and applications
30/05/2024 - Starch and chitosan, polysaccharides derived from natural sources, have significant potential across various domains. Starch is extracted from starch?bearing plants, such as potatoes, whereas...
Synthesis, In vitro and In silico Studies of Novel bis?triazolopyridopyrimidines from Curcumin Analogues as Potential Aromatase Agents
03/06/2024 - This study aims to combat breast cancer, which is a significant health concern for women worldwide. By targeting aromatase, an enzyme crucial in estrogen synthesis, the research focuses on breast...
Phytochemical Profiling and Biological Activity of the Methanolic extracts of Cirsium monspessulanum (L.) Hill.
03/06/2024 - The study of new plant species and the identification of their chemical composition may contribute to the discovery of a new breakthrough substances for pharmacotherapeutical applications. For the...
Innovative Fusion: Natural Compound?Rhein and PROTACs Unleash Potent VEGFR?2 Degraders
31/05/2024 - VEGFR?2 is a prominent therapeutic target in antitumor drug research to block tumor angiogenesis. This study focused on the synthesis and optimization of PROTACs based on the natural product rhein,...
Peimenine unleashes therapeutic promise in urothelial bladder cancer: inhibition of proliferation, induction of cell death and modulation of key pathways
29/05/2024 - In this study, PEI upregulated the expression levels of BIM, BAK1, and CYCS proteins in EJ?1 and BIU?87 cells, leading to mitochondrial apoptosis in UBC cell.Peimenine (PEI) is a steroid alkaloid...
Strategies to Design Chemocatalytic Racemization of Tertiary Alcohols: State of the Art & Utilization for Dynamic Kinetic Resolution
29/05/2024 - In the challenging field of racemizing tertiary alcohols, recently different concepts were developed. Suitable catalysts for efficient racemization and suppressing unwanted side?reactions were found....