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Decoding Drug Discovery: Exploring A-to-Z In Silico Methods for Beginners
- Abstract The drug development process is a critical challenge in the pharmaceutical industry due to its time-consuming nature and the need to discover new drug potentials to...
Monolith Catalyst Design by Combining 3D Printing and Atomic Layer Deposition: Toward Green Palladium‐Catalyzed Cross‐Coupling Reactions
21/11/2024 - This study combines 3D printing and atomic layer deposition to design SiOC ceramic monoliths with palladium nanoparticles, enhancing Suzuki–Miyaura cross‐coupling reactions. The 3D structure...
Harnessing Lignin Nanoparticles for Sustainable Enzyme Immobilization: Current Paradigms and Future Innovations
- Abstract Lignin, a vital plant component, is key in providing structural integrity and is the second most abundant biopolymer in nature. The growing interest in sustainable and...
AtLEC2‐Mediated Enhancement of Endoplasmic Reticulum‐Targeted Foreign Protein Synthesis in Nicotiana benthamiana Leaves: Insights From Transcriptomic Analysis
26/11/2024 - This study presents a novel strategy to enhance foreign protein accumulation through transient expression in the leaves of Nicotiana benthamiana. The overexpression of AtLEC2 specifically enhances...
Enzymatic Cleavage of Double?Stranded DNA?Encoded Libraries (DELs) to Single?Stranded DELs with Compounds at the 3? End: Its Application in Photo?Crosslinking Selection
19/11/2024 - In this study, we developed a novel method for converting double?stranded DNA?encoded libraries (dsDELs) to single?stranded DELs (ssDELs) with compounds at the 3’ end using cleavabledeoxyuridine....
Sustainable Extraction of Bioactive Compounds and Nutrients from Agri-Food Wastes: Potential Reutilization of Berry, Honey, and Chicory Byproducts
21/11/2024 - Several agri-food byproducts represent valuable sources of compounds to be reutilized for nutritional, nutraceutical, and cosmetic purposes. Examples especially comprise byproducts from the...
The Value of Using Green Extraction Techniques to Enhance Polyphenol Content and Antioxidant Activity in Nasturtium officinale Leaves
20/11/2024 - Increasing research is being directed toward the production of value-added products using plant extracts that are super-fortified with antioxidants. In this study, the extraction parameters for...
A Nanodiamond-Based Electrochemical Sensor for the Determination of Paracetamol in Pharmaceutical Samples
20/11/2024 - This study presents an electrochemical sensor developed from a glassy carbon electrode modified with nanodiamond film (ND/GCE). This electrochemical response of the proposed sensor was improved, and...
Chemical Composition, Structural Properties, and Bioactivity of Carrageenan from Field-Cultivated Betaphycus gelatinus
20/11/2024 - This study investigates seasonal biomass variations in Betaphycus gelatinus, a red alga cultivated in the field in Ninh Thuan, Vietnam, along with the chemical composition, structural properties, and...
Nutritional Composition and Functional Properties of A. platensis-Derived Peptides: A Green and Sustainable Protein-Rich Supplement
20/11/2024 - Among cyanobacterium, Arthrospira platensis (A. platensis) is a rich source of diverse bioactive compounds due to its high protein, essential amino acid, vitamin, and mineral content....
Sono?Triggered Biomimetically Nanoantibiotics Mediate Precise Sequential Therapy of MRSA?Induced Lung Infection
14/11/2024 - AMV@NanoCip, a novel biomimetic nanomedicine, integrates PBP2a antibody?presenting nanovesicles with self?assembled ciprofloxacin nanoparticles exhibiting sonodynamic properties. This formulation...
Production of Polylactide Nanoparticles Loaded With Isoniazid and Vitamin C: A Promising Candidate for the Treatment of Resistant Forms of Tuberculosis
16/11/2024 - ABSTRACTNowadays, the method of directed transport of drugs is becoming increasingly important in medicine and pharmacology. It allows for increasing the concentration of delivered substances in a...
Microfluidic Fabrication of Oleosin-Coated Liposomes as Anticancer Drug Carriers with Enhanced Sustained Drug Release
13/11/2024 - Microfluid-derived liposomes (M-Lipo) exhibit great potential as drug and functional substance carriers in pharmaceutical and food science. However, the low liposome membrane stability, attributed to...
Highly Sensitive Trimetazidine Determination Using Composite Yttria-Stabilized Zirconia Doped with Titanium Oxide–Carbon Black Biosensor
14/11/2024 - A novel composite voltammetric biosensor has been developed for the first time, utilizing a glassy carbon electrode modified with yttria-stabilized zirconia doped with titanium dioxide and carbon...
Pharmaceutical Removal with Photocatalytically Active Nanocomposite Membranes
- The advancement of pharmaceutical science has resulted in the development of numerous tailor-made compounds, i.e., pharmaceuticals, tuned for specific drug targets. These compounds are often...
Enhanced Rheological and Structural Properties of the Exopolysaccharide from Rhizobium leguminosarum VF39 Through NTG Mutagenesis
15/11/2024 - Microbial exopolysaccharides (EPSs) are biopolymer materials with advantages such as biodegradability, biocompatibility, ease of mass production, and reproducibility. The EPS that was isolated from...
The Promising Role of Amine Transaminase Cascades in the Synthesis of Non-Canonical Amino Acids
16/11/2024 - Amine transaminases (ATA) are critical players in producing non-canonical amino acids, essential building blocks in pharmaceuticals and fine chemicals. Significant progress has been made in...
Production, Characterization and Application of Biosurfactant for Cleaning Cotton Fabric and Removing Oil from Contaminated Sand
18/11/2024 - Biosurfactants are a group of environmentally friendly amphiphilic molecules that are applicable in numerous industries as essential biotechnology products, such as food production, cleaning...
Unveiling the Biological Activities, Pharmacological Potential, and Health Benefits of Sorbifolin: A Comprehensive Review
13/11/2024 - Bioactive phytochemicals act as important factors with preventive and therapeutic potential in the pathogenesis of several disorders, often related to oxidative stress. Many dietary plant secondary...
Synthesis, Biological Evaluation, and Molecular Docking Studies of Indole?Based Heterocyclic Scaffolds as Potential Antibacterial Agents
13/11/2024 - Indole?based heterocyclic scaffolds have become increasingly important in medicinal chemistry due to their notable pharmacological and biological properties. Their role in the discovery and...
Novel Polyvinyl Alcohol: Polyacrylic Acid Nanofiber Composite for Prolonged Release of Capecitabine: In Vitro and In Vivo Evaluations of Colon-Targeted Drug Delivery
14/11/2024 - Cancer is a leading cause of death in the world. Recent research studies have mainly focused on available treatments without problems. Recently, advances in nanotechnology have revolutionized the...