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Colorimetric determination of carbidopa in anti-Parkinson drugs based on 4-hydroxy-3-methoxybenzaldazine formation by reaction with vanillin
- In this paper is reported the selective colorimetric detection and quantification of carbidopa, an inhibitor of aromatic amino acid decarboxylase, in the co-presence of levodopa as dopamine...
Resource Utilization of Bovine Neck Ligament: Enzymatic Preparation of Elastin Peptide and Its Antioxidant Activity
- Abstract Elastin is considered an excellent resource for obtaining antioxidant peptides due to unique amino acid composition. However, it is hardly soluble in water or in...
Endoplasmic reticulum-targeted inhibition of CYP2E1 with vitamin E nanoemulsions alleviates hepatocyte oxidative stress and reverses alcoholic liver disease
- Alcoholic liver disease (ALD) is a global healthcare problem and socioeconomic issue that is primarily driven by chronic and/or excessive alcohol consumption. Upon alcohol exposure, parenchymal...
Multimodal imaging of capsid and cargo reveals differential brain targeting and liver detargeting of systemically-administered AAVs
- The development of gene delivery vehicles with high organ specificity when administered systemically is a critical goal for gene therapy. We combine optical and positron emission tomography (PET)...
A strategy for screening novel umami dipeptides based on common feature pharmacophore and molecular docking
- To shorten the complex and tedious process of traditional umami peptide identification, a novel model based on common feature pharmacophore (HipHop, a ligand molecule-based screening method) and...
Discovery of derivatives from Spartina alterniflora-sourced moiety as xanthine oxidase inhibitors to lower uric acid
01/10/2022 - In this work, hit compounds Spartinin F1-F20 sharing the Spartina alterniflora-sourced ferulic acid backbone were synthesized and evaluated on inhibiting xanthine oxidase...
Ultrasensitive electrochemical sensor for the detection of carbamazepine based on gadolinium vanadate nanostructure decorated functionalized carbon nanofiber nanocomposite
- The gadolinium vanadate nanostructure decorated functionalized carbon nanofiber (GdVO4/f-CNF) nanocomposite was prepared by the hydrothermal method, which is fabricated on a glassy carbon electrode...
Drug screening approach against mycobacterial fatty acyl-AMP ligase FAAL32 renews the interest of the salicylanilide pharmacophore in the fight against tuberculosis
01/10/2022 - Tuberculosis (TB) remains a global health crisis, further exacerbated by the slow pace of new treatment options, and the emergence of extreme and total drug resistance to existing drugs. The...
Effect of alkaline washing treatment on leaching behavior of municipal solid waste incineration bottom ash
04/08/2022 - This study aimed to find an effective, inexpensive, and safe washing treatment for municipal solid waste incineration bottom ash (MSWIBA) in order to reduce its potential harmful effects in...
Chiral Recognition with Broad Selective Sensor Arrays
04/08/2022 - The detection and discrimination of chiral analytes has always been a topical theme in food and pharmaceutical industries and environmental monitoring, especially when dealing with chiral drugs and...
Extraction, Structural Analysis, and Biofunctional Properties of Exopolysaccharide from Lactiplantibacillus pentosus B8 Isolated from Sichuan Pickle
04/08/2022 - Two novel exopolysaccharides, named LPB8-0 and LPB8-1, were isolated and purified from Lactiplantibacillus pentosus B8. Moreover, their structure and bioactivities were evaluated through chemical and...
Elicitation Promoability with Gamma Irradiation, Chitosan and Yeast to Perform Sustainable and Inclusive Development for Marjoram under Organic Agriculture
04/08/2022 - Sweet marjoram (Majorana hortensis) is an important aromatic herbal plant that has long been used and well managed in the traditional and general medical, pharmaceutical, food, cosmetic, and perfume...
Quality Risk Management in Pharmaceutical Manufacturing Operations: Case Study for Sterile Product Filling and Final Product Handling Stage
04/08/2022 - In the highly regulated pharmaceutical industry, significant risks to products/processes must be formally identified, reduced, and controlled to minimize potential negative impacts on patients....
Antifouling surface for biomedical devices: Modification of COC surface by quaternary ammonium moieties via diazonium chemistry
- Prefilled biomedical devices (PFD) are growing in the pharmaceutical market due to the ease of delivering a precise dose of protein drugs. As an appealing alternative to the fragile glass, cyclic...
Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer’s disease
01/10/2022 - The search for new drug candidates against Alzheimer’s disease (AD) remains a complex challenge for medicinal chemists due to its multifactorial pathogenesis and incompletely understood...
Human serum albumin-based propulsive Piperlongumine-loaded nanoparticles: Formulation development, characterization and anti-cancer study
- Piperlongumine (PL) is a naturally occurring bioactive plant alkaloid, endowed with potential pharmacological activities, such as anti-inflammatory, antidiabetic, anti-atherosclerotic, anticancer...
Formulation, characterization, pharmacokinetics and antioxidant activity evaluation of Pinus koraiensis nuts oil based coenzyme Q10 loaded nanoemulsion
- Coenzyme Q10(CoQ10) is a well-known lipophilic antioxidant with good prospects for practical application of different fields including foods and pharmaceutics but has the drawback of low oral...
Arylation Reactions in the Synthesis of Biologically Important 2,5-Diaryl-1,3,4-Oxadiazoles
03/08/2022 - Apart from carbon atoms, some cyclic molecules contain other elements and play an extraordinary role in human life. Among these systems, 1,3,4-oxadiazole derivatives deserve special attention due to...
Bird Cherry (Prunus padus) Fruit Extracts Inhibit Lipid Peroxidation in PC Liposomes: Spectroscopic, HPLC, and GC–MS Studies
03/08/2022 - The antioxidant potential of bird cherry fruit of water, methanol, ethanol, and acetone extracts and their antioxidant efficiency against oxidation of PC liposomes using spectroscopic and...
BODIPY-Based Nanomaterials—Sensing and Biomedical Applications
03/08/2022 - Cancerous diseases are rightfully considered among the most lethal, which have a consistently negative effect when considering official statistics in regular health reports around the globe....