Envase
Envase
Assessing food by-products macrocomposition by FTIR microspectroscopy
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Food by-products offer a promising opportunity for extracting valuable compounds that can be used in the food, pharmaceutical, and polymer industries. However, unpredictable variations in the...
Becoming fully circular facilitated by PAT
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Process analytical technologies (PAT) have contributed to helping industrial processes become more efficient, more sustainable, safer, and more reliable for more than two decades. Real-time...
Genetically Engineered Yeast for Enhanced Biodegradation of Î-lactam Antibiotics
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High environmental concentrations of pharmaceuticals, particularly antibiotics, have been observed worldwide, while antibiotic concentrations in the ng/L to µg/L range may adversely affect...
Exploring the Potential Mechanism of Action of Ursolic Acid for Parkinson’s Disease: An Integrative Network Pharmacology, Docking and Molecular Dynamics Study
24/06/2025 -
Airborne laser scanning technology is widely used in photogrammetry and remote sensing, enabling three-dimensional information about objects located on the Earth’s surface to be obtained. In...
Thienopyrimidine: Unveiling the Versatile Potential of a Promising Heterocyclic Scaffold in Drug Discovery
19/06/2025 -
ABSTRACTFused pyrimidine scaffolds serve as a flexible and versatile foundational heterocycle in the field of pharmaceutical development. Thienopyrimidines are a diverse family of molecules...
Anti‐Osteoporosis Activity of Lycopene Through ESR1: Network Pharmacology, Molecular Docking, Imaging Technology, and Experimental Validation
12/06/2025 -
Schematic of the mechanism of LYC in treating osteoporosis through the ESR1/PI3K/AKT pathway. LYC upregulates ESR1 expression and thus leads to the activation of the PI3K/AKT pathway, thereby...
Central Composite Design Based Optimization of Carbohydrate Coated Albumin Nanoparticles for HCC: Synthesis, Extensive Characterization and In Vivo Pharmacokinetic Evaluation
29/05/2025 -
ABSTRACTHepatocellular carcinoma (HCC) is one serious cause of cancer‐associated deaths worldwide. Poor bioavailability and non‐specific targeting of drugs is a challenge. Gemcitabine (GEM) is...
Discovery of 1‐(Cyclopropylmethyl)‐2‐(Dibenzo[b,d]Thiophen‐2‐yl)‐1H‐Benzo[d]Imidazole‐5‐Carboxylic Acid as Orally Bioavailable EP4 Receptor Antagonist
31/05/2025 -
Despite significant research in the past decades, no EP4 antagonist has been approved for human use yet. The scaffold‐hopping approach, in combination with docking studies, synthesis, and...
Atomic Scale Engineering of Multivalence‐State Palladium Photocatalyst for Transfer Hydrogenation with Water as a Proton Source
22/05/2025 -
Photocatalytic transfer hydrogenation is achieved over a multivalence‐state palladium photocatalyst, in which protons generated from photocatalytic water splitting are added to unsaturated double...
Optimizing federated learning efficiency: accelerating model averaging with cluster-based approach using class occurrences - fedCCO
22/05/2025 -
Overweight and obesity are major risk factors for heart failure (HF), contributing to its development through metabolic, neurohormonal, haemodynamic, and inflammatory alterations. While...
Sicher durch die Quartalsabrechnung
20/05/2025 -
Simvastatin is one the most commonly used drugs for treatment of hypercholesterolemia but suffers from low bioavailability (about 5%) owing to poor aqueous solubility and extensive first pass...
Zu Gast in der Praxis von ...
20/05/2025 -
Background Thyroid hormones influence the function of essentially every system of the body, including the cardiovascular and metabolic system. Thyroid hormone replacement with...
Expert panel as reference standard procedure in diagnostic accuracy studies: a systematic scoping review and methodological guidance
13/05/2025 -
Background Adverse drug reactions (ADRs) have a significant impact on the healthcare system worldwide. Underreporting of ADRs is identified as a main issue in pharmacovigilance....
A Comprehensive Review on the Advancements of Dual COX‐2/5‐LOX Inhibitors as Anti‐Inflammatory Drugs
10/05/2025 -
This review explores the latest advancements in dual COX‐2/5‐LOX inhibitors, highlighting their potential as effective anti‐inflammatory agents with improved safety profiles compared to...
Synthesis Methods and Therapeutic Journey of Carprofen and Its Derivatives: A Review
10/05/2025 -
Although it is currently only used in veterinary therapy, carprofen proves to be a molecule with a versatile therapeutic potential for human pharmacotherapy. Moreover, the molecule is a target in the...
Micromotion‐Driven “Mechanical‐Electrical‐Pharmaceutical Coupling” Bone‐Guiding Membrane Modulates Stress‐Concentrating Inflammation Under Diabetic Fractures
06/05/2025 -
Micromotion activates a “mechano‐electro‐pharmaceutical” system, converting mechanical energy to electrical cues that trigger Met release. These cues suppress inflammation via M1‐M2...
Exploring Antibacterial, Antioxidant, Cytotoxic Potential of Oscillatoria sp.-Derived Metabolites and Their Molecular Docking with Estrogen Receptor-α
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Anthropogenic activities have led to the accumulation of carcinogenic toxicants in the food chain, posing severe risks to both human and animal health. Bioactive molecules derived from terrestrial...
Phosphatidylcholine Liposome Accelerated Platinum Nanomachines (PLANEs) With Enhanced Penetration Capability for Thrombus Mechanotherapy
24/04/2025 -
This work introduces a phosphatidylcholine (PC) liposome coating strategy for nanomotors. The isotropic and lubricating PC liposome enhances the linear motion and reduces friction of platinum...
Efficient and sustainable recovery of bioactive compounds from cashew nut testa shell (Anacardium occidentale L.) using pressurized liquid extraction
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Cashew nut processing generates large quantities of byproducts daily, such as cashew nut testa shell (CNTS), which is discarded, leading to environmental and economic issues. However, CNTS...
Optimized Biosynthetic Pathway for Nonnatural Amino Acids: An Efficient Approach for L‐2‐Aminobutyric Acid Production
23/04/2025 -
ABSTRACTL‐2‐Aminobutyric acid (L‐2‐ABA) is a nonnatural chiral α‐amino acid which is widely used in various chiral pharmaceuticals and medical intermediates. Currently, the microbial...
