Envase
Envase
Sustainable Biosynthesis of Fludarabine by a Novel Mixed Nanostabilized Biocatalyst
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The purine analogue, 2-fluoroadenine-9-β-D-arabinofuranoside, better known as fludarabine, is a widely used drug for cancer treatment. Nowadays, it is mainly synthesized by chemical methods,...
Discovery and Functional Characterization of SnFDHal, an Efficient Tryptophan 5-Halogenase from Streptomyces noursei
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Flavin-dependent halogenases (FDHs) are a class of enzymes renowned for their regioselective ability to precisely insert halogen atoms into small aromatic compounds. Halogen incorporation can...
Protein Kinase Inhibitors: Synthesis and Molecular Repurposing in Three‐Dimensional Cancer Models PKI
06/11/2025 -
The review analyzes of pharmacological niche of protein kinase inhibitors, synthesis methods and mechanism of action of existing approved drugs‐inhibitors of major protein kinases. Also modern...
Investigation Into the Inhibition of Ferroptosis by Praeruptorin‐A in Sepsis Based on Network Pharmacology
06/11/2025 -
Identification of the effective molecular targets of PA during sepsis using network pharmacology. PA has the potential to inhibit LPS‐induced ferroptosis in macrophages. PA exerts its inhibitory...
Production and Characterisation of Mobilisin, a Broad-Spectrum Antimicrobial Peptide from Bacillus mobilis
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Antimicrobial peptides offer significant potential in addressing antimicrobial resistance, as pathogens develop low or no resistance against them. This study aimed to isolate and screen...
Review of Polysaccharides/Proteins Combine With Metals: A New Strategy for Wound Healing Therapy
05/11/2025 -
ABSTRACTWound dressing is crucial for managing wound healing, protecting wounds from the environment, and accelerating the healing process. Recently, wound dressing is evolving from traditional to...
Emerging Roles of Biopolymers in Seed Science and Technology
04/11/2025 -
ABSTRACTBiopolymers are naturally occurring macromolecules derived from renewable biological sources such as plants, animals, and microorganisms. Their intrinsic biodegradability, biocompatibility,...
Development of an analytical method for emerging contaminants including the pharmaceuticals recently selected as key performance indicators of the quaternary treatment of urban wastewater
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The revised European Directive concerning Urban Wastewater Treatment introduced the quaternary treatment for micro-pollutants. This directive lists 13 substances used as indicators of the...
Investigational Anticancer Potential and Targeted Delivery Aspects of Benzyl Isothiocyanate (BITC) in Breast Cancer Treatment
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Breast cancer (BC) remains the most commonly diagnosed cancer among women worldwide and a leading cause of cancer-related mortality. Despite advances in early detection and treatment modalities,...
Synthesis and Molecular Modeling Studies of New Thiadiazole‐Thiophene Compounds as Potent Antimicrobial Agents
31/10/2025 -
ABSTRACTEight thiadiazole‐thiophene hybrids 4, 5, 6, and 7 were prepared by incorporating a thiophene ring system into the precursor 2‐(cyanomethyl)‐1,3,4‐thiadiazole compounds 3a and 3b,...
Design and Synthesis of 2‐Aminopyrazolpyrimidopyridone Derivatives as RETV804M and RETG810C Kinase Inhibitors
31/10/2025 -
One of the 2‐aminopyrazolpyrimidopyridone derivatives 7–40 suppressed BaF3 cells harboring CCDC6‐RETV804M and CCDC6‐RETG810C mutations with IC50 values of 0.841 and 0.272 μM, respectively....
From conventional to miniaturized workflows: a critical review of sample preparation methods for nonsteroidal anti-inflammatory drug analysis
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Non-steroidal anti-inflammatory drugs (NSAIDs) are extensively used pharmaceuticals that persist in biological fluids, environmental waters, and food, raising concerns for therapeutic monitoring,...
Computational Evaluation of Potential c-Abl Kinase Inhibitors for Parkinsonâs Disease: QSAR, Docking, Bioisosteric Replacement, ADMET, and MD Simulations
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Inhibiting c-Abl kinase pharmacologically is necessary because of its role in oxidative stress and neurodegeneration. When activated, it causes the accumulation of α-synuclein and dopaminergic...
Dynamic D‐Allose Monitoring Via a Toggle‐Programmed Microbial Fluorescent Biosensor
26/10/2025 -
ABSTRACTRecently, microbial fermentation for the synthesis of rare sugars has garnered considerable attention. d‐Allose, a rare monosaccharide, has emerged as a significant bioproduct in the food...
A category approach to characterize river sites based on non-target screening and target analysis
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The objective of this study was to characterize monitoring sites with regard to their contaminating sources and to identify potential pollution hotspots as well as previously unknown compounds....
Green Synthesis of Silver Nanoparticles Using Cynoglossum creticum Leaf Extract: Eco-Friendly Approach for Antibacterial, Antioxidant, and Sensing Applications
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Nanotechnology leveraging renewable plant biomass to develop silver nanoparticles offers eco-friendly solutions with more sustainable applications. The present research explores the employment of...
Stress Responsive Glycosyltransferase (UGT72Z7) from Glycyrrhiza glabra Showed Glycosylation of Azadirachtin
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Uridine diphosphate glycosyltransferases (UGTs) play crucial roles in the glycosylation of plant metabolites, contributing to growth, defense, and stress adaptation. Despite their importance, UGT...
Modeling and Optimization of Ultrasound-Assisted Extraction of Antioxidants from Yerba Mate (Ilex paraguariensis St. Hill) Using Artificial Neural Networks and ANFIS
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The leaves of yerba mate, commonly found in the southern region of Brazil, are consumed as teas and contain a variety of antioxidant compounds with nutritional and pharmacological value. This...
Talaromyces sayulitensis as a Potential Bioremediation Agent for Metformin
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Contamination of pharmaceutical compounds in aquatic environments is an escalating concern requiring urgent intervention. The widespread use and improper disposal of pharmaceuticals cause both...
A review of the recent advances in extraction techniques for volatilome of aromatic and fragrant plants
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The last decade has witnessed an increase in the development of extraction techniques for volatile components from different matrices. Meanwhile, analytical methods have shifted toward the...
