Otros
Otros
Bioengineered Tumor‐Stroma Prostate Cancer In Vitro Models for Screening Therapeutics
13/03/2025 -
This study presents the establishment of 3D bioengineered prostate cancer tumor‐stroma spheroid models, designed to more accurately replicate the complex interactions between cancer cells and the...
An Examination of Aerosol Jet‐Printed Surface Roughness and its Impact on the Performance of High‐Frequency Electronics
11/03/2025 -
This study explores aerosol jet‐printed (AJP) surface roughness, its effects on the performance of microwave electronics, and its process contributors. First, an electromagnetic model is vetted for...
High‐Capacity Volumetric Methane Storage in Hyper‐Cross‐Linked Porous Polymers via Flexibility Engineering of Building Units
12/03/2025 -
An unprecedented flexible porous polymer HCP‐DPP, constructed by the flexible building unit with the rigid external crosslinker, achieves a desirable trade‐off between porosity and density while...
3D Printable Self‐Healing Mineralized Hydrogels Loaded With Diclofenac Sodium: In Vitro and In Vivo Assessment
12/03/2025 -
ABSTRACTThe use of self‐healing mineralized hydrogels in 3D printing has demonstrated significant advantages, including enhanced printing accuracy and the ability to maintain high shape fidelity...
Ultra‐High Bending Angle of Miniaturized Piezoelectric Actuator Screen‐Printed on Stiff Substrate
27/02/2025 -
The miniaturization of electroactive soft polymer bending actuators is highly desirable as their fields of application are very broad. However, challenges such as performance loss limit their...
Geometry‐Assisted Phase Selection: Interplay of Phase Heterogeneity and Geometry in Gyroid Shell Metamaterials Printed with 17‐4 PH Stainless Steel
18/02/2025 -
This study explores geometry‐driven phase evolution in gyroid shell metamaterials made via laser powder bed fusion of 17‐4 precipitation hardened stainless steel. Locally hardened regions develop...
99mTc‐HYNIC PEGylated Peptide Probe Targeting HER2‐Expression in Breast Cancer
19/02/2025 -
Introduction of PEG12 chain had a positive influence also on the pharmacokinetics demonstrating significantly improved tumour activity and target‐to‐non‐target ratios proving...
Assessment of Phytochemical Profile, Antioxidant, and Anticancer Activity Against Colon Cancer-HT-29: A Potent Therapeutic Medicinal Plant (Tarenna alpestris) in Megamalai Hills, Western Ghats, India
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Abstract Medicinal plants have long been recognized as a valuable source of human health due to their therapeutic potential in treating a variety of diseases. Tarenna...
Demonstrating the Effectiveness of an Alternative to Triton X‐100 for Detergent‐Mediated Viral Inactivation in Biomanufacturing
05/02/2025 -
ABSTRACTDetergent‐mediated viral inactivation is an important process step for ensuring viral safety of parenteral biotherapeutics, including plasma proteins and monoclonal antibodies (mAb). The...
Adenocarpine, Marmesin, and Lycocernuine from Ficus benjamina as Promising Inhibitors of Aldose Reductase in Diabetes: A Bioinformatics-Guided Approach
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Abstract Diabetes affects approximately 422 million people worldwide, leading to 1.5 million deaths annually and causing severe complications such as kidney failure, neuropathy,...
Metabolomic Analysis and Computational Biology Reveal the Potential Metabolic Pathways for Improvement of Fucoxanthin and Eicosapentaenoic Acid (EPA) Biosynthesis in Phaeodactylum tricornutum
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Abstract This work aims to provide a basis for the enhancement of fucoxanthin (FCX) and eicosapentaenoic acid (EPA) biosynthesis in the microalga Phaeodactylum...
Prediction of Multi-targeting Pharmacological Activity of Bioactive Compounds from Medicinal Plants Against Hepatocellular Carcinoma Through Advanced Network Pharmacology and Bioinformatics-Based Investigation
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Abstract The primary objective of this study was to identify bioactive compounds from four medicinal plants with multi-targeting activity against hepatocellular carcinoma (HCC). A...
Advanced Polymeric Nanoparticles for Cancer Immunotherapy: Materials Engineering, Immunotherapeutic Mechanism and Clinical Translation
10/01/2025 -
Here recent advances in engineered polymeric nano‐paradigms that are uniquely suited to enhance the therapeutic efficacy of cancer immunotherapy while decreasing the immune response associated...
In Vitro Cytotoxic Potential and Integrated Network Pharmacology, Molecular Docking and Molecular Dynamic Approaches to Decipher the Mechanism of Gymnostachyum febrifugum Benth., in the Treatment of Breast Cancer
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Abstract Gymnostachyum febrifugum, a less-known ethnomedicinal plant from the Western Ghats of India, is used to treat various diseases and serves as an antioxidant and...
Three‐Dimensional Fluid Flow Over an Elastic Sheet Stretched Nonlinearly in Two Lateral Directions
07/01/2025 -
This study analyse a bulk flow of nanoparticles flow that is incompressible and caused by a surface that has been nonlinearly stretched in both laterally and longitudinally. The permeable...
Working with technical purity: simulation of red tattoo pigment metabolism by online-liquid chromatography-electrochemistry-mass spectrometry
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Tattooing is a popular form of body art that has evolved from ancient times into being part of modern society. The understanding of biotransformation processes of coloring tattoo pigments in human...
An In Silico Approach to Uncover Selective JAK1 Inhibitors for Breast Cancer from Life Chemicals Database
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Abstract JAK1, a key regulator of multiple oncogenic pathways, is a sought-out target, and its expression in immune cells and tumour-infiltrating lymphocytes (TILs) is associated...
Quercetin Derivatives from Bidens pilosa Suppressed Cell Proliferation via Inhibition of RSK2 Kinase and Aldose Reductase Enzymes: UPLC-MS/MS, GCâMS, In Vitro, and Computational Studies
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Abstract Traditionally, Bidens pilosa L. is an edible herb utilized for various ailments. The study accomplished a complete analysis of B. pilosa...
Identification of putative volatile biomarkers of canine leishmaniasis in dog’s breath and hair employing a novel algorithm for automated chromatographic peak detection and matching
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The analysis of the volatile compounds released by biological samples represents a promising approach for the non-invasive diagnosis of a disease. The present study, focused on a population of...
