Bioplásticos
Bioplásticos
Development of reference materials for dietary supplements—analytical challenges, use, limitations, and future needs
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For two decades, the National Institute of Standards and Technology (NIST) and the National Institutes of Health Office of Dietary Supplements have collaborated to develop dietary...
Porous Silicon Nanoneedles Efficiently Deliver Adenine Base Editor to Correct a Recurrent Pathogenic COL7A1 Variant in Recessive Dystrophic Epidermolysis Bullosa
12/03/2025 -
Base editing using nanoneedles efficiently corrects pathogenic variants in the type VII collagen gene of primary fibroblasts from patients with recessive dystrophic epidermolysis bullosa. Nanoneedle...
Self‐Healable Hydrogel for Regression of Liver Fibrosis
07/03/2025 -
The effects of a chitosan–phenol‐based hydrogel, which undergoes fast gelling and possesses self‐healing and injectable properties, on mimicking liver tissue and promoting the regression of...
Selective determination of 3,5-dihydroxycinnamic acid in urine samples as gluten intake biomarker: high-performance thin-layer chromatography combined with colorimetric detection
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The determination of biomarkers is a significant field of analytical chemistry research under continuous evolution that contributes to enhance diagnostics and enable more personalized medicine....
Engineered Stem Cell Booster Breaks Pathological Barriers to Treat Chronic Pancreatitis
27/02/2025 -
In the treatment of chronic pancreatitis with mesenchymal stem cells (MSCs), two main pathological barriers are encountered: 1) Fibrotic collagen hinders cell delivery, and 2) Malignant...
Biomimetic rhCOL17‐P334 Conjugate for Enhanced Wound Healing
23/02/2025 -
This study presents a novel bioscaffold combining recombinant human collagen XVII (rhCOL17) with porphyra‐334 (P334) to create a transparent, injectable hydrogel (GCP) for enhanced wound healing....
The Influence of Cuprorivaite Nanoparticles on the Physicomechanical and Biological Performance of 3D‐Printed Scaffold Based on Carboxymethyl Chitosan Combined With Zein for Bone Tissue Engineering
13/02/2025 -
ABSTRACTThis study demonstrates a new degradable 3D‐printed carboxymethyl chitosan (CMC)/zein bone scaffold loaded with different content of cuprorivaite (Cup) nanoparticles which labeled as...
A 3D Bioprinted Gelatine‐Based Bilayer Hydrogel Dressing Loaded With Curcumin and Ciprofloxacin Hydrochloride With Antibacterial, Anti‐Inflammatory and Antioxidative Properties
16/02/2025 -
Graphical Abstract and Lay SummarySchematic diagram of gelatin/sodium alginate bilayer hydrogels loaded with ciprofloxacin hydrochloride and curcumin.ABSTRACTSkin wound repair, a highly integrated...
Osteomimix: A Multidimensional Biomimetic Cascade Strategy for Bone Defect Repair
09/02/2025 -
A multidimensional biomimetic cascade strategy for bone regeneration is developed by emulating the biomineralization cascade, hierarchical structure, and biological functions of bone tissue. The...
Functional Biomaterials Derived from Protein Liquid–Liquid Phase Separation and Liquid‐to‐Solid Transition
09/02/2025 -
Protein can undergo liquid–liquid phase separation and liquid‐to‐solid transition to form liquid condensates and solid aggregates. These phase transitions can be influenced by...
Tissue Mimetic Membranes for Healing Augmentation of Tendon–Bone Interface in Rotator Cuff Repair
31/01/2025 -
Here, a tissue‐mimetic membrane for functional tendon–bone interface regeneration is fabricated. During the implantation, a biomimicry and inductive microenvironment is created by the...
Osteochondral Tissue Engineering: Scaffold Materials, Fabrication Techniques and Applications
25/01/2025 -
Graphical Abstract and Lay Summary The research on osteochondal tissue engineering scaffolds is developing rapidly, offering new possibilities for osteochondral damage. This review introduces...
Leveraging Optical Anisotropy of the Morpho Butterfly Wing for Quantitative, Stain‐Free, and Contact‐Free Assessment of Biological Tissue Microstructures
15/01/2025 -
We leverage the intrinsic optical anisotropy of the Morpho butterfly wing to introduce Morpho‐Enhanced Polarized Light Microscopy (MorE‐PoL), a stain‐ and contact‐free imaging methodology...
CircZMYM2 Alleviates TGF-β1-Induced Proliferation, Migration and Activation of Fibroblasts via Targeting miR-199b-5p/KLF13 Axis
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Abstract Dysregulated circular RNAs (circRNAs) has been revealed to be involved in pulmonary fibrosis progression. Herein, this study focused on exploring the function and...
Polyproline‐Polyornithine Diblock Copolymers with Inherent Mitochondria Tropism
10/01/2025 -
This study presents the synthesis and characterization of polypeptide‐based diblock copolymers with inherent mitochondria‐targeting properties. Utilizing a scalable 2‐step polymerization...
Rationally Engineering Pro‐Proteins and Membrane‐Penetrating α‑Helical Polypeptides for Genome Editing Toward Choroidal Neovascularization Treatment
24/12/2024 -
Adenosine triphosphate‐tagged pro‐proteins are engineered to form stable nanocomplexes with guanidyl‐rich, α‐helical polypeptide and enable robust cytosolic delivery. By delivering...
Renal Clearable Chiral Manganese Oxide Supraparticles for In Vivo Detection of Metalloproteinase‐9 in Early Cancer Diagnosis
23/12/2024 -
Chiral MnO2 supraparticles as renal‐clearance biosensors for dual‐mode in vivo detection of metalloproteinase‐9 in early cancer diagnosis via circular dichroism (CD) and magnetic resonance...
A One‐Stone‐Two–Birds Strategy for Intervertebral Disc Repair: Constructing a Reductive Chelation Hydrogel to Mitigate Oxidative Stress and Promote Disc Matrix Reconstruction
23/12/2024 -
HA‐NCSN/Cu is a new type of hydrogel formed by reducing crosslinking, which shows multi‐functions such as injectable, self‐healing, reactive oxygen species clearance, photothermal properties,...
Recent Research on Chondrocyte Dedifferentiation and Insights for Regenerative Medicine
24/12/2024 -
ABSTRACTChondrocytes maintain the balance of the extracellular matrix by synthesizing glycoproteins, collagen, proteoglycans and hyaluronic acid. Chondrocyte dedifferentiation refers to a process in...
An Immunomodulatory Hydrogel Featuring Antibacterial and Reactive Oxygen Species Scavenging Properties for Treating Periodontitis in Diabetes
28/11/2024 -
An immunomodulatory hydrogel is developed to treat periodontitis in diabetes. This formulation combines chlorhexidine acetate, epigallocatechin‐3‐gallate, gelatin methacryloyl, and oxidized...
Sequence and Configuration of a Novel Bispecific Antibody Format Impacts Its Production Using Chinese Hamster Ovary (CHO) Cells
25/11/2024 -
Bispecific BYbe® format sequence and configuration impacts secretory titre. Variable fragment (Fv) sequence and placement can reduce or enhance titre. Vector development strategies that allow tuning...
