Materiales avanzados
Materiales avanzados
A Tightly Interlayer Bonded, Synchronously In Situ Co‐Injectable, Wet‐Adhesive, Hierarchically Biofunctionalized Bilayer Hydrogel for Functional Attachment and Orderly Periodontal Regeneration
22/09/2026 -
An interlayer‐bonded, synchronously in situ co‐injectable, wet‐adhesive, hierarchically biofunctionalized bilayer hydrogel was developed for coordinated regeneration of alveolar bone and...
Pathology‐Responsive Self‐Assembling Hydrogel Enabling Spatiotemporally Controlled Exosome Release and Redox Regulation for Intervertebral Disc Regeneration
25/07/2026 -
Turning a destructive enzymatic signal into a therapeutic trigger, this work presents an MMP‐13‐responsive self‐assembling hydrogel for pathology‐matched exosome delivery. By combining...
Diblock Copolymer Engineered Swim Bladder Membrane Enables Spatiotemporal Synchronized Defense and Pro‐Healing in Challenging Soft Tissue Regeneration
06/07/2026 -
PPEGMA‐b‐PTHFuA engineered swim bladder membrane orchestrates spatiotemporal synchronized degradation, defense and pro‐healing. Benefitting from the naturally dense fish swim bladder network...
Photo‐Crosslinking Aided Hierarchical Assembly of Recombinant Collagen Hydrogels for 3D Bio‐Printing
17/06/2026 -
Graphical Abstract and Lay SummaryThe recombinant collagen prepared in our study can form self‐supported hydrogels through modifications, while retaining integrity of triple helix structure and...
Bidirectional Brain‐Machine Communication and Neuromodulation by Supramolecular Hydrogel Neural Probes for Chronic Pain Management
12/05/2026 -
A supramolecular hydrogel probe based on α‐helical polypeptide cross‐linkers was developed, achieving an optimal balance of mechanical compliance, electrical conductivity, and optical...
Tissue‐Conforming Organoselenium Hydrogel with Microphase‐Controlled Acylhydrazone Crosslinking Kinetics Expedites Diabetic Wound Healing by Inhibiting AGE‐RAGE Pathways
14/03/2026 -
We report a tissue‐conforming organoselenium hydrogel (TCOH) that leverages microphase separation to control acylhydrazone crosslinking kinetics, thereby integrating exceptional wound...
From Synthesis to Therapeutics: Bioactive‐Coated Zein Nanoparticles in Drug Delivery
15/03/2026 -
ABSTRACTPolymeric zein nanoparticles (ZNP), derived from corn protein, are biodegradable drug carriers with high stability and low synthesis costs. Their amphiphilic nature allows efficient...
Dynamic, Reconfigurable, and Hierarchical Biosynthetic Composites via Collagen Self‐Assembly within Highly Crowded Microgel Pastes
06/12/2025 -
A new approach to extracellular matrix‐mimetic, hierarchical biomaterials is presented. Soft gels composed of overpacked hydrogel microparticle arrays present a biomolecularly crowded environment...
Review of Polysaccharides/Proteins Combine With Metals: A New Strategy for Wound Healing Therapy
05/11/2025 -
ABSTRACTWound dressing is crucial for managing wound healing, protecting wounds from the environment, and accelerating the healing process. Recently, wound dressing is evolving from traditional to...
Advances in ε‐Poly‐Lysine Biosynthesis, Selection of High‐Yielding Strains and Regulatory Mechanisms
01/09/2025 -
Graphical Abstract and Lay Summaryε‐Polylysine (ε‐PL) is a natural antimicrobial peptide widely used in food preservation and pharmaceuticals, but its low‐yield and high‐cost limit...
An Ultrapotent, Ultraeconomical, Antifreeze Polypeptide
28/08/2025 -
Simple and inexpensive polypeptides composed of random copolymers of alanine and glutamic acid are effective antifreezes for applications in foods and biomedicine. The polypeptides, inspired by...
Zinc‐Coordinated Trienzyme Nanogel Cascade Therapy for Accelerated Post‐Pancreatectomy Cutaneous Wound Healing
31/07/2025 -
A zinc‐coordinated nanogel assembly is reported that co‐delivers three enzymes to regulate glucose, oxidative stress, and oxygen levels. This system mimics natural enzyme cascades to reprogram...
Light‐Activated Transient Unilateral Adhesive Recombinant Collagen‐Based Hydrogel for Reversible Fibrosis Induction and Full‐Cycle Management of Pancreatic Fistula
11/07/2025 -
A light‐activated, injectable recombinant collagen‐based hydrogel plug with targeted drug delivery is developed for full‐cycle management of pancreatic fistula. Featuring enzyme resistance,...
Green Agarose Hydrogel Implants With High Biocompatibility for Skin Repair and Regeneration in Photoaged Skin
29/05/2025 -
ABSTRACTSkin aging is a multifaceted process marked by the destruction of skin structure and the diminishment of skin function, significantly impacting both physical and mental health. Injectable...
Dynamic GelMA/DNA Dual‐Network Hydrogels Promote Woven Bone Organoid Formation and Enhance Bone Regeneration
23/03/2025 -
A dynamic, dual‐network CGDE hydrogel, combining covalent and noncovalent crosslinking mimics the biochemical and mechanical cues of bone extracellular matrix. This viscoelastic matrix promotes 3D...
Biomimetic rhCOL17‐P334 Conjugate for Enhanced Wound Healing
23/02/2025 -
This study presents a novel bioscaffold combining recombinant human collagen XVII (rhCOL17) with porphyra‐334 (P334) to create a transparent, injectable hydrogel (GCP) for enhanced wound healing....
Osteomimix: A Multidimensional Biomimetic Cascade Strategy for Bone Defect Repair
09/02/2025 -
A multidimensional biomimetic cascade strategy for bone regeneration is developed by emulating the biomineralization cascade, hierarchical structure, and biological functions of bone tissue. The...
A One‐Stone‐Two–Birds Strategy for Intervertebral Disc Repair: Constructing a Reductive Chelation Hydrogel to Mitigate Oxidative Stress and Promote Disc Matrix Reconstruction
23/12/2024 -
HA‐NCSN/Cu is a new type of hydrogel formed by reducing crosslinking, which shows multi‐functions such as injectable, self‐healing, reactive oxygen species clearance, photothermal properties,...
Structural and Viscoelastic Properties of Bacterial Cellulose Composites: Implications for Prosthetics
18/11/2024 -
This study investigates the morphological, mechanical, and viscoelastic properties of bacterial cellulose (BC) hydrogels synthesized by the microbial consortium Medusomyces gisevii. BC gel films were...
Design and Synthesis of Dual Galectin?3 and EGFR Inhibitors Against Liver Fibrosis
06/11/2024 -
Liver fibrosis, mainly arising from chronic viral or metabolic liver diseases, is a significant global health concern. There is currently only one FDA?approved drug (Resmetirom) in the market to...
Exploring the Potential of Anthocyanins for Repairing Photoaged Skin: A Comprehensive Review
01/11/2024 -
Long-term exposure to ultraviolet (UV) rays can result in skin photoaging, which is primarily characterized by dryness, roughness, pigmentation, and a loss of elasticity. However, the clinical drugs...
